ISSN 2312-3672
Dudanova O., Marina M., Pisareva M., Grudinin M. Extrahepatic manifestations in patients with chronic hepatitis C // Journal of Biomedical Technologies. 2014. № 1. P. 18‒24. DOI: 10.15393/j6.art.2014.3001
Issue № 1 (2014)
| Dudanova Olga Petrovna | Petrozavodsk State University, 185910 Petrozavodsk, Lenina str, 33, Russia, odudanova@gmail.com |
| Marina Marina E | Petrozavodsk State University, 185910 Petrozavodsk, Lenina str, 33, Russia, odudanova@gmail.com |
| Pisareva Maria M | Research Institute of Influenza of the Ministry of Health, Saint-Petersburg, Russia, odudanova@gmail.com |
| Grudinin Mikhail P | Research Institute of Influenza of the Ministry of Health, Saint-Petersburg, Russia, odudanova@gmail.com |
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extrahepatic manifestations chronic hepatitis C genotype 1 genotype 3a |
The aim of the study was to determine extrahepatic manifestations (EHM) of chronic hepatitis C (CHC) in patients with genotype 1 and 3a infections.
Materials and methods. We examined 83 patients with CHC: 42 (50.6%) with genotype 1, and 41 (49.4%) with genotype 3a; 49 (59.0%) were males, 34 (41.0%) were females; the mean ± SD age of patients was 39.3±12.3 (range: 17 – 72) years. Chronic hepatitis was diagnosed in 75 (90.4%) patients, and cirrhosis – in 8 (9.6%). Clinical, laboratory, histological, biochemical and virological data (AbHCV, viral RNA) were obtained.
Results. EHM were observed in 27 (32.5%) patients: in 18 (42.9%) with genotype 1 infection, and in 9 (21.9%) with genotype 3a infection. The following manifestations were diagnosed: arthralgia (14.5%), purpura (8.4%), glomerulonephritis (6.0%), thyroiditis (6.0%), type 2 diabetes mellitus (3.6%), non-Hodgkin lymphoma (1.2%), Raynoud’s phenomenon (1.2%), psoriasis (1.2%), vitiligo (1.2%). Cryoglobulinemia was detected in 9 (10.8%) patients. On average, EHM were revealed 2 times more frequently in females (25.3%) than in males (7.2%).
Conclusion. Extrahepatic manifestations in CHC were observed in 32.5% of patients, more frequently in patients infected with genotype 1 virus and in females, than in patients with genotype 3a infection and males. |
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