|Petrozavodsk State University, 33 Lenin str., Petrozavodsk, Russia 185910, firstname.lastname@example.org|
|Petrozavodsk State University, 33 Lenin str., Petrozavodsk, Russia 185910, email@example.com|
|Petrozavodsk State University, 33 Lenin str., Petrozavodsk, Russia 185910, VolkovaTO@yandex.ru|
Ability to induce lymphangiogenesis (LA) and epithelial-to-mesenchymal transition (EMT) has been recognized as one of the major features of tumor cells of epithelial origin and as an essential prerequisite for their invasion and metastasis. It has been proposed that acquisition of invasion/migration capacity is an early event in the course of cervical cancer development denoting the establishment of malignant phenotype, but relatively few experimental data concerning the mechanisms that supportLA and EMT at early stages of cervical cancer are currently available. The article describes expression profiles obtained for a selected set of key genes involved in the regulation of LA and EMT (growth factors, their receptors, transcription factors, and multidrug resistance proteins) which correspond to major steps of invasive cancer development, including benign cervical lesions, cervical intraepithelial neoplasia grade 1-3, intraepithelial carcinoma, or cancer in situ, and microinvasive cancer in comparison with normal epithelium. Here we show stage-specific expression patterns for genes belonging to different functional groups. We were also able to reveal some intergenic relationships that corroborated early activation and cross-regulation of corresponding signaling pathways in vivo. The results indicate that the development of squamous cell cervical carcinoma may represent an appropriate natural model for studying mechanisms of LA and EMT regulation.