ISSN 2312-3672
Shubina M., Dudanova O., Cehanovich K. Portal blood flow disturbance in chronic viral hepatitis b and its possible impact on affection of pancreas // Journal of Biomedical Technologies. 2014. № 2. P. 25‒33. DOI: 10.15393/j6.art.2014.3205
Issue № 2 (2014)
Original research
Portal blood flow disturbance in chronic viral hepatitis b and its possible impact on affection of pancreas
| Shubina Marina E | Petrozavodsk State University, Petrozavodsk, Russia, odudanova@gmail.com |
| Dudanova Olga P | Petrozavodsk State University, Petrozavodsk, Russia, odudanova@gmail.com |
| Cehanovich Konstantin B | Clinical hospital at the station Petrozavodsk, Petrozavodsk, Russia, odudanova@gmail.com |
|
chronic viral hepatitis B portal blood flow dopplerography pancreas |
Background. The research was aimed at dopplerography study of possible changes in portal blood flow in the early stages of chronic viral hepatitis B and the impact of these changes on structural and functional parameters of the pancreas.
Materials and methods. The study included 92 patients with chronic viral hepatitis B. Assessment of portal blood flow was carried out on the basis of ultrasound and Doppler sonography of diameter of the portal system veins – the portal (PV) and splenic veins (SV), and the value of the linear and volumetric blood flow velocity in them, the «index of stagnation» was determined as well. Exocrine pancreatic function was estimated by α-amylase activity of the serum. Structural changes in the pancreas were assessed on the basis of ultrasound data.
Results. In patients with chronic viral hepatitis B (at the stage of hepatitis) the change in the parameters of the portal blood flow (PBF) was observed, namely an increase in vessel diameter of the PV system, the reduction in the linear blood flow velocity (LBFV) of the PV and of the SV, a progressive increase in «index of stagnation», indicating the initial manifestations of impairments of the PBF, and the development of venous stasis in the PV. These changes were detected at the LBFV PV from 18.0 to 16.2 cm/s and peaked at LBFV PV from 14.0 to 12.0 cm/s. Incremental change of the PBF was correlated with the activity of the pathological process in the liver. Parallelism between the increase of a disorder of the PBF and the frequency and/or the degree of functional and structural changes of the pancreas, including an increase of its size, was revealed.
Conclusion. Slowing of blood flow in the PV and SV develops early in the course of chronic viral hepatitis, forming a syndrome of portal hypertension. An active pathological process in the liver represents the main factor at the stage of chronic hepatitis influencing the change of the PBF. The shift of the PBF in the PV is accompanied by changes in the structure and exocrine pancreatic function. The development of venous stasis in the pancreas is assumed to be one of the possible pathogenic mechanisms of its damage during deceleration of PBF. |
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