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Korneva V., Kuznetsova T. Epicardial fat thickness in patients with familial hypercholesterolemia // Journal of Biomedical Technologies. 2015. № 1. P. 16‒22. DOI: 10.15393/j6.art.2015.3262


Issue № 1 (2015)

Original research

Epicardial fat thickness in patients with familial hypercholesterolemia

Korneva
   Victoria A.
Petrozavodsk State University, Petrozavodsk, Lenina str 33, vikkorneva@mail.ru
Kuznetsova
   Tatyana Yu.
Petrozavodsk State University, Petrozavodsk, Lenina str 33, vikkorneva@mail.ru
familial hypercholesterolemia
epicardial fat.
Epicardial fat (EF), or epicardial adipose tissue, is a visceral fat deposit around the heart. The association between epicardial fat thickness (EFT) and the frequency of fatal and non-fatal cardiovascular events was revealed in previous studies. Aim. To evaluate the EFT in patients with familial hypercholesterolemia (FH) compared with patients with normal lipid profile. Materials and methods. Forty seven normotensive FH patients without ischemic heart disease (and who didn’t receive lipid-lowering therapy) and forty one normotensive patients with normal lipid profile were examined. EFT was assessed by echocardiography. Results. Regardless of body mass index, in FH patients, EFT was higher (4.4±0.24 mm) than in patients with normal lipid spectrum (3.7±0.23 mm), p=0.03. Among individuals with excessive body mass index, EFT was higher in FH patients than that of the controls (4.6±0.22 mm and 3.69±0.27 mm, respectively, p=0.009). The maximum difference in EFT between FH patients and persons with normal lipid profile (4.31±0.22 mm and 3.52±0.19 mm, respectively (p=0.004)) was observed for women. Conclusions. A significantly higher EFT level was revealed in FH patients, regardless of the presence of overweight.

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