ISSN 2312-3672
Kolomeychuk S., Korneva V., Ilukha V., Kuznetsova A., Kuznetsova T. The study of polymorphic variants of matrix metalloproteinase (mmp-3) gene as a risk marker of arterial hypertension and ischemic heart disease development among the population of the Republic of Karelia // Journal of Biomedical Technologies. 2014. № 2. P. 10‒16. DOI: 10.15393/j6.art.2014.3202
Issue № 2 (2014)
Original research
The study of polymorphic variants of matrix metalloproteinase (mmp-3) gene as a risk marker of arterial hypertension and ischemic heart disease development among the population of the Republic of Karelia
| Kolomeychuk Sergey N | Petrozavodsk State University, Karelian Research Centre of the Russian Academy of Sciences, Petrozavodsk, Russia, sergey_kolomeychuk@rambler.ru |
| Korneva Victoria A | Petrozavodsk State University, Petrozavodsk, Russia, sergey_kolomeychuk@rambler.ru |
| Ilukha Vladimir V | Petrozavodsk State University, Petrozavodsk, Russia, sergey_kolomeychuk@rambler.ru |
| Kuznetsova Anastasia S | Petrozavodsk State University, Petrozavodsk, Russia, sergey_kolomeychuk@rambler.ru |
| Kuznetsova Tatyana Yu | Petrozavodsk State University, Petrozavodsk, Russia, sergey_kolomeychuk@rambler.ru |
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arterial hypertension cardiovascular diseases matrix metalloproteinases genetic polymorphism biomarkers plasma lipoproteins |
Hypertension is a pathological state associated with vascular remodeling characterized by qualitative and quantitative changes in the content of the extracellular matrix. Collagen degradation is mainly governed by the activity of matrix metalloproteinases, enzymes having a wide range of biological functions. The leading role among the latter is given to metalloproteinase-3 (MMP-3). A number of epidemiological studies of MMP-3 5A/6A genetic variants showed that this marker is associated with various cardiovascular diseases in different ethnic groups.
The aim of our study was to investigate the possibility of using of metalloproteinase-3 SNP as a marker of hypertension in the population of Russia/Republic of Karelia. We analyzed blood samples from 174 healthy donors (without clinical manifestations) and 198 blood samples of hypertensive patients.
In our sample 5A and 6A allele frequencies of the SNP marker were not significantly different between control group and patients with hypertension. Analysis of gender ratio in MMP-3 genotype distribution in men and women showed no significant differences between patients and controls. We have found that 5A5A MMP-3 homozygotes are associated with elevated levels of glucose, total cholesterol and triglycerides in hypertensive patients. Significant impact of MMP-3 gene polymorphic variants on atherogenic lipid fraction levels (both LDL and total cholesterol was detected in controls in comparison to the hypertensives. |
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