ISSN 2312-3672
Vinogradova I., Yunash V., Bukalev A., Zabezhinsky M., Anisimov V. Synthetic peptide of the pineal gland can decrease morbidity and age-related pathology in male-rats kept in conditions of accelerated aging caused by disruption of photoperiodism // Journal of Biomedical Technologies. 2014. № 1. P. 25‒36. DOI: 10.15393/j6.art.2014.3021
Issue № 1 (2014)
Original research
Synthetic peptide of the pineal gland can decrease morbidity and age-related pathology in male-rats kept in conditions of accelerated aging caused by disruption of photoperiodism
| Vinogradova Irina Anatolievna | Petrozavodsk State University, 185000, Russian Federation, the republic of Karelia, Petrozavodsk, Lenina st., 33, irinav@petrsu.ru |
| Yunash Victoria Dmitrievna | Petrozavodsk State University, 185000, Russian Federation, the republic of Karelia, Petrozavodsk, Lenina st., 33, yunashvd@petrsu.ru |
| Bukalev Andrey Victorovich | V.A. Baranov Republic Hospital, 185019, Russian Federation, the republic of Karelia, Petrozavodsk, Pirogova st., 3, max-andy@yandex.ru |
| Zabezhinsky Mark Abramovich | N.N. Petrov Research Institute of Oncology, 197758, St. Petersburg, pos. Pesochny,Str. Leningradskya, 68, irinav@petrsu.ru |
| Anisimov Vladimir Nikolaevich | N.N. Petrov Research Institute of Oncology, 197758, St. Petersburg, pos. Pesochny,Str. Leningradskya, 68, irinav@petrsu.ru |
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synthetic peptide of pineal gland photoperiodism circadian rhythms |
Protective effects of synthetic peptide Ala-Glu-Asp-Gly in different light regimens (standard 12/12 light/dark – LD), natural lightning of the North-West of Russia (the Republic of Karelia – NL), constant light ( LL) on the development of age-related pathology and morbidity in male rats were studied. From the age of 4 months to 24 months animals were kept in different light regimens and received a course of short epiphyseal peptide injections.
Data obtained confirm the role of circadian rhythms in etiopathogenesis of various diseases and tumor growths. It was revealed that the use of the synthetic peptide Ala-Glu-Asp-Gly reduced morbidity and incidence of age-related pathology in male rats and exerted the most protective effect in the conditions of accelerated aging caused by disruption of photoperiodism. It was shown that tetrapeptide Ala-Glu-Asp-Gly had geroprotective, anti-tumor and immunoprotective properties and improved resistance of an organism to stress factors. |
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